Synthesis and cytotoxic activity of N-(2-pyridylsulfenyl)urea derivatives.: A new class of potential antineoplastic agents.

被引：24

作者：

Gil, MJ

Mañú, MA

Arteaga, C

Migliaccio, M

Encío, I

González, A

Martínez-Merino, V

机构：

[1] Univ Publ Navarra, Dept Quim, Pamplona 31006, Spain

[2] Univ Publ Navarra, Dpto Ciencias Salud, Pamplona 31008, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 16期

关键词：

D O I：

10.1016/S0960-894X(99)00373-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Starting from a 3D-model for the antineoplastic activity of diarylsulfonylureas several new features were proposed and tested. Both types of assayed compounds, the N-(2-pyridylsulfonyl)urea and N-(2-pyridylsulfenyl)urea derivatives, inhibited by 50% the growth of the CCRF-CEM cell line at a dosage near to 1 mu M The N-(2-pyrimidinyl) derivative of the sulfenylurea 6c showed a better profile against HT-29, K-562 and HTB-54 tumor cell lines than the corresponding sulfonylurea 6b. Structural modifications on aryl systems affected differently to the cytotoxic activity shown by the compounds against each cell line. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2321 / 2324

页数：4

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