MIF:: a new cytokine link between rheumatoid arthritis and atherosclerosis

被引：292

作者：

Morand, EF

Leech, M

Jürgen, B

机构：

[1] Monash Inst Med Res, Ctr Inflammatory Dis, Clayton, Vic 3168, Australia

[2] RWTH Univ Hosp, Inst Biochem, Dept Biochem & Mol Cell Biol, D-52074 Aachen, Germany

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 05期

关键词：

D O I：

10.1038/nrd2029

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Macrophage migration inhibitory factor (MIF) is well established as a key cytokine in immuno-inflammatory diseases such as rheumatoid arthritis. Inflammation is now also recognized as having a crucial role in atherosclerosis, and recent evidence indicates that MIF could also be important in this disease. Here, we review the role of MIF in rheumatoid arthritis and atherosclerosis, discuss the ways in which MIF and its relationship with glucocorticoids could link these diseases, and consider the potential of MIF as a new therapeutic target for small-molecule and antibody-based anti-cytokine drugs.

引用

收藏

页码：399 / 410

页数：12

相关论文

共 132 条

[1] Endogenous macrophage migration inhibitory factor modulates glucocorticoid sensitivity in macrophages via effects on MAP kinase phosphatase-1 and p38 MAP kinase [J].

Aeberli, D ;

Yang, Y ;

Mansell, A ;

Santos, L ;

Leech, M ;

Morand, EF .

FEBS LETTERS, 2006, 580 (03) :974-981

[2] ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis [J].

Al-Abed, Y ;

Dabideen, D ;

Aljabari, B ;

Valster, A ;

Messmer, D ;

Ochani, M ;

Tanovic, M ;

Ochani, K ;

Bacher, M ;

Nicoletti, F ;

Metz, C ;

Pavlov, VA ;

Miller, EJ ;

Tracey, KJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (44) :36541-36544

[3]

Amoli MM, 2002, J RHEUMATOL, V29, P1671

[4] Premature coronary-artery atherosclerosis in systemic lupus erythematosus [J].

Asanuma, Y ;

Oeser, A ;

Shintani, AK ;

Turner, E ;

Olsen, N ;

Fazio, S ;

Linton, MF ;

Raggi, P ;

Stein, CM .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (25) :2407-2415

[5] Enhancement of oxidised low-density lipoprotein uptake by macrophages in response to macrophage migration inhibitory factor [J].

Atsumi, T ;

Nishihira, J ;

Makita, Z ;

Koike, T .

CYTOKINE, 2000, 12 (10) :1553-1556

[6] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].

AUPHAN, N ;

DIDONATO, JA ;

ROSETTE, C ;

HELMBERG, A ;

KARIN, M .

SCIENCE, 1995, 270 (5234) :286-290

[7] An essential regulatory role for macrophage migration inhibitory factor in T-cell activation [J].

Bacher, M ;

Metz, CN ;

Calandra, T ;

Mayer, K ;

Chesney, J ;

Lohoff, M ;

Gemsa, D ;

Donnelly, T ;

Bucala, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7849-7854

[8] Anti-inflammatory actions of glucocorticoids: molecular mechanisms [J].

Barnes, PJ .

CLINICAL SCIENCE, 1998, 94 (06) :557-572

[9] A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis [J].

Baugh, JA ;

Chitnis, S ;

Donnelly, SC ;

Monteiro, J ;

Lin, X ;

Plant, BJ ;

Wolfe, F ;

Gregersen, PK ;

Bucala, R .

GENES AND IMMUNITY, 2002, 3 (03) :170-176

[10] Biochemical and nutational investigations of the enzymatic activity of macrophage migration inhibitory factor [J].

Bendrat, K ;

AlAbed, Y ;

Callaway, DJE ;

Peng, T ;

Calandra, T ;

Metz, CN ;

Bucala, R .

BIOCHEMISTRY, 1997, 36 (49) :15356-15362

← 1 2 3 4 5 6 7 8 9 10 →