Interference of linoleic acid fraction in some receptor binding assays

被引：21

作者：

Ingkaninan, K

Künzel, JKVD

IJzerman, AP

Verpoorte, R

机构：

[1] Leiden Univ, Gorlaeus Labs, Leiden Amsterdam Ctr Drug Res, Div Pharmacognosy, NL-2300 RA Leiden, Netherlands

[2] Leiden Univ, Gorlaeus Labs, Leiden Amsterdam Ctr Drug Res, Div Med Chem, NL-2300 RA Leiden, Netherlands

来源：

JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 06期

关键词：

D O I：

10.1021/np9805490

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An extract of a suspension culture of Tabernaemontana pandacaqui Poir. was fractionated by centrifugal partition chromatography. Aliquots were tested in an adenosine A(1) receptor binding assay. This led to the isolation and identification of linoleic acid, which proved to be a noncompetitive inhibitor This "false positive" effect also extended to some other binding assays.

引用

页码：912 / 914

页数：3

共 15 条

[1]

COX EH, 1997, THESIS LEIDEN U NETH, P91

[2]

Foucault A.P., 1995, CENTRIFUGAL PARTITIO

[3] A REFINED METHOD FOR THE PHOTOAFFINITY-LABELING OF THE NITROBENZYLTHIOINOSINE-SENSITIVE NUCLEOSIDE TRANSPORT PROTEIN - APPLICATION TO CELL-MEMBRANES OF CALF LUNG-TISSUE [J].

IJZERMAN, AP ;

MENKVELD, GJ ;

THEDINGA, KH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 979 (02) :153-156

[4] Comparison of some centrifugal partition chromatography systems for a general separation of plant extracts [J].

Ingkaninan, K ;

Hermans-Lokkerbol, ACJ ;

Verpoorte, R .

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, 1999, 22 (06) :885-896

[5] CHARACTERIZATION OF PLATELET-ACTIVATING-FACTOR BINDING TO HUMAN AIRWAY EPITHELIAL-CELLS - MODULATION BY FATTY-ACIDS AND ION-CHANNEL BLOCKERS [J].

KANG, JX ;

MAN, SFP ;

HIRSH, AJ ;

CLANDININ, MT .

BIOCHEMICAL JOURNAL, 1994, 303 :795-802

[6]

KATO J, 1989, J STEROID BIOCHEM, V34, P219

[7] INTERACTION OF BARBITURATES WITH ADENOSINE RECEPTORS IN RAT-BRAIN [J].

LOHSE, MJ ;

LENSCHOW, V ;

SCHWABE, U .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1984, 326 (01) :69-74

[8] 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE (DPCPX) - A SELECTIVE HIGH-AFFINITY ANTAGONIST RADIOLIGAND FOR A1 ADENOSINE RECEPTORS [J].

LOHSE, MJ ;

KLOTZ, KN ;

LINDENBORNFOTINOS, J ;

REDDINGTON, M ;

SCHWABE, U ;

OLSSON, RA .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1987, 336 (02) :204-210

[9] EFFECT OF TERPENOID PRECURSOR FEEDING AND ELICITATION ON FORMATION OF INDOLE ALKALOIDS IN CELL-SUSPENSION CULTURES OF CATHARANTHUS-ROSEUS [J].

MORENO, PRH ;

VANDERHEIJDEN, R ;

VERPOORTE, R .

PLANT CELL REPORTS, 1993, 12 (12) :702-705

[10] A NEW CENTRIFUGAL COUNTERCURRENT CHROMATOGRAPH AND ITS APPLICATION [J].

MURAYAMA, W ;

KOBAYASHI, T ;

KOSUGE, Y ;

YANO, H ;

NUNOGAKI, Y ;

NUNOGAKI, K .

JOURNAL OF CHROMATOGRAPHY, 1982, 239 (APR) :643-649

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