Higher-Order Assemblies in a New Paradigm of Signal Transduction

被引：273

作者：

Wu, Hao ^{[1
,2
]}

机构：

[1] Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

CELL | 2013年 / 153卷 / 02期

基金：

美国国家卫生研究院;

关键词：

CRYSTAL-STRUCTURE; RECEPTOR; COMPLEX; ACTIVATION; APOPTOSIS; MECHANISM; REVEALS; KINASE; TRAF6; FORMS;

D O I：

10.1016/j.cell.2013.03.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecular mechanisms in proximity-driven enzyme activation, threshold behavior, signal amplification, reduction of biological noise, and temporal and spatial control of signal transduction.

引用

收藏

页码：287 / 292

页数：6

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