A role for leptin in hemopoieses?

被引：43

作者：

Gainsford, T ^{[1
]}

Alexander, WS ^{[1
]}

机构：

[1] Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

MOLECULAR BIOTECHNOLOGY | 1999年 / 11卷 / 02期

基金：

英国医学研究理事会;

关键词：

leptin; cytokine; obesity; hemopoiesis; blood cells;

D O I：

10.1007/BF02915808

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recent discovery of leptin as a major controller of appetite has led to a detailed analysis of its specific actions in this process as well as any potential role in the etiology of obesity. It has. also emerged that leptin has a wider spectrum of biological activities and has been strongly implicated in fertility and production. The structural similarity between leptin and its receptor and cytokine-receptor systems that control hemopoiesis has also prompted investigation of the potential for this hormone to influence blood cell formation; Recent studies have shown that the leptin receptor is expressed on a diverse range of hemopoietic cells. Leptin itself appears to enhance proliferation of hemopoietic cells in vitro, particularly in combination with other cytokines and may augment some mature hemopoietic cell functions. Although only relatively minor hemopoietic deficiencies have been reported in mice lacking:leptin. or its receptor, these emerging studies suggest that further analysis of leptin actions in hemopoiesis may be warranted.

引用

页码：149 / 158

页数：10

共 91 条

[11] Early onset of reproductive function in normal female mice treated with leptin [J].

Chehab, FF ;

Mounzih, K ;

Lu, RH ;

Lim, ME .

SCIENCE, 1997, 275 (5296) :88-90

[12] Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice [J].

Chen, H ;

Charlat, O ;

Tartaglia, LA ;

Woolf, EA ;

Weng, X ;

Ellis, SJ ;

Lakey, ND ;

Culpepper, J ;

Moore, KJ ;

Breitbart, RE ;

Duyk, GM ;

Tepper, RI ;

Morgenstern, JP .

CELL, 1996, 84 (03) :491-495

[13] Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor [J].

Chua, SC ;

Chung, WK ;

WuPeng, XS ;

Zhang, YY ;

Liu, SM ;

Tartaglia, L ;

Leibel, RL .

SCIENCE, 1996, 271 (5251) :994-996

[14] Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr) [J].

Chua, SC ;

White, DW ;

WuPeng, XS ;

Liu, SM ;

Okada, N ;

Kershaw, EE ;

Chung, WK ;

PowerKehoe, L ;

Chua, M ;

Tartaglia, LA ;

Leibel, RL .

DIABETES, 1996, 45 (08) :1141-1143

[15] Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human [J].

Chung, WK ;

PowerKehoe, L ;

Chua, M ;

Leibel, RL .

GENOME RESEARCH, 1996, 6 (05) :431-438

[16] Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction [J].

Cioffi, JA ;

Shafer, AW ;

Zupancic, TJ ;

SmithGbur, J ;

Mikhail, A ;

Platika, D ;

Snodgrass, HR .

NATURE MEDICINE, 1996, 2 (05) :585-589

[17] Indication for linkage of the human OB gene region with extreme obesity [J].

Clement, K ;

Garner, C ;

Hager, J ;

Philippi, A ;

LeDuc, C ;

Carey, A ;

Harris, TJR ;

Jury, C ;

Cardon, LR ;

Basdevant, A ;

Demenais, F ;

GuyGrand, B ;

North, M ;

Froguel, P .

DIABETES, 1996, 45 (05) :687-690

[18] A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction [J].

Clément, K ;

Vaisse, C ;

Lahlou, N ;

Cabrol, S ;

Pelloux, V ;

Cassuto, D ;

Gourmelen, M ;

Dina, C ;

Chambaz, J ;

Lacorte, JM ;

Basdevant, A ;

Bougneres, P ;

Lebouc, Y ;

Froguel, P ;

Guy-Grand, B .

NATURE, 1998, 392 (6674) :398-401

[19] EFFECTS OF PARABIOSIS OF OBESE WITH DIABETES AND NORMAL MICE [J].

COLEMAN, DL .

DIABETOLOGIA, 1973, 9 (04) :294-298

[20] OBESE AND DIABETES - 2 MUTANT-GENES CAUSING DIABETES-OBESITY SYNDROMES IN MICE [J].

COLEMAN, DL .

DIABETOLOGIA, 1978, 14 (03) :141-148

← 1 2 3 4 5 6 7 8 9 10 →