Sensitivity of sup35 and sup45 suppressor mutants in Saccharomyces cerevisiae to the anti-microtubule drug benomyl

被引：28

作者：

Tikhomirova, VL

IngeVechtomov, SG

机构：

[1] Department of Genetics and Breeding, Sankt-Petersburg University, University Emb. 7/9, 199034, Sankt-Petersburg

来源：

CURRENT GENETICS | 1996年 / 30卷 / 01期

关键词：

omnipotent suppression; microtubules; respiratory deficiency; Saccharomyces cerevisiae;

D O I：

10.1007/s002940050098

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

SUP35 and SUP45 genes determine the accuracy of translation at the stage of termination. We present indirect evidence indicating that these genes may also control some cellular process mediated by microtubules. A majority of sup35 and sup45 suppressor mutations confer supersensitivity to benomyl, the drug which de-polymerizes microtubules. In addition, data correlating phenotypic manifestations of sup45 suppressor mutations, involving sensitivity to benomyl, respiratory deficiency and a suppressor effect, are also presented.

引用

页码：44 / 49

页数：6

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