Consistency of isochromosome 7q and trisomy 8 in hepatosplenic γδ T-cell lymphoma:: Detection by fluorescence in situ hybridization of a splenic touch-preparation from a pediatric patient

被引：20

作者：

Coventry, S

Punnett, HH

Tomczak, EZ

Casher, D

Koehler, M

Borowitz, MJ

Griffin, CA

de Chadarévian, JP

机构：

[1] St Christophers Hosp Children, Dept Pathol, Philadelphia, PA 19134 USA

[2] St Christophers Hosp Children, Dept Lab Med, Sect Cytogenet, Philadelphia, PA 19134 USA

[3] St Christophers Hosp Children, Dept Pediat, Philadelphia, PA 19134 USA

[4] St Christophers Hosp Children, Hematol Oncol Sect, Philadelphia, PA 19134 USA

[5] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21287 USA

[6] Johns Hopkins Univ, Sch Med, Ctr Oncol, Baltimore, MD 21287 USA

来源：

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY | 1999年 / 2卷 / 05期

关键词：

hepatosplenic lymphoma; trisomy; 8; isochromosome; 7q; fever of unknown origin;

D O I：

10.1007/s100249900152

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Hepatosplenic gamma-delta (gamma delta) T-cell lymphoma is a rare but increasingly recognized lymphoid malignancy predominantly affecting young adult males. It is not well appreciated in the pediatric population. We report the third case of this aggressive lymphoma in a child as well as additional support for the consistency of the recently discovered cytogenetic abnormalities, isochromosome 7q and trisomy 8, which in this case were documented using fluorescence in situ hybridization (FISH) of a touch-preparation of the spleen.

引用

页码：478 / 483

页数：6

共 24 条

[21] Gamma/delta T-cell hepatosplenic lymphoma: Review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia [J].