Two theonellapeptolide congeners from marine sponge Theonella sp.

被引：19

作者：

Tsuda, M

Shimbo, K

Kubota, T

Mikami, Y

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chiba 2608673, Japan

来源：

TETRAHEDRON | 1999年 / 55卷 / 34期

关键词：

D O I：

10.1016/S0040-4020(99)00586-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new theonellapeptolide-related cyclic depsipeptides (1 and 2) have been isolated from an Okinawan marine sponge Theonella sp. and the structures were elucidated on the basis of the 2D NMR data, PSD analysis of MALDI-TOFMS, and chemical means. Compound 1 was a theonellapeptolide congener possessing a methylsulfinylacetyl group at the N-terminus, while 2 was another theonellapeptolide congener having an acetyl group at the N-terminus. Compounds 1 and 2 exhibited antimicrobial activity. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：10305 / 10314

页数：10

相关论文

共 16 条

[1]

Faulkner DJ, 1998, NAT PROD REP, V15, P113

[2] KERAMAMIDE F, A NEW THIAZOLE-CONTAINING PEPTIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

ITAGAKI, F ;

SHIGEMORI, H ;

ISHIBASHI, M ;

NAKAMURA, T ;

SASAKI, T ;

KOBAYASHI, J .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (20) :5540-5542

[3] MASS-SPECTROMETRIC SEQUENCING OF LINEAR PEPTIDES BY PRODUCT-ION ANALYSIS IN A REFLECTRON TIME-OF-FLIGHT MASS-SPECTROMETER USING MATRIX-ASSISTED LASER-DESORPTION IONIZATION [J].

KAUFMANN, R ;

SPENGLER, B ;

LUTZENKIRCHEN, F .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1993, 7 (10) :902-910

[4] MARINE NATURAL-PRODUCTS .25. BIOLOGICALLY-ACTIVE TRIDECAPEPTIDE LACTONES FROM THE OKINAWAN MARINE SPONGE THEONELLA-SWINHOEI (THEONELLIDAE) (1) - STRUCTURE OF THEONELLAPEPTOLIDE ID [J].

KITAGAWA, I ;

LEE, NK ;

KOBAYASHI, M ;

SHIBUYA, H .

TETRAHEDRON, 1991, 47 (12-13) :2169-2180

[5]

KITAGAWA I, 1986, CHEM PHARM BULL, V34, P2664

[6]

KITAGAWA I, 1987, CHEM PHARM BULL, V35, P2129

[7] KERAMAMIDE-E, KERAMAMIDE-G, KERAMAMIDE-H AND KERAMAMIDE-J, NEW CYCLIC-PEPTIDES CONTAINING AN OXAZOLE OR A THIAZOLE RING FROM A THEONELLA SPONGE [J].

KOBAYASHI, J ;

ITAGAKI, F ;

SHIGEMORI, H ;

TAKAO, T ;

SHIMONISHI, Y .

TETRAHEDRON, 1995, 51 (09) :2525-2532

[8] KERAMAMIDE-A, A NOVEL PEPTIDE FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

KOBAYASHI, J ;

SATO, M ;

ISHIBASHI, M ;

SHIGEMORI, H ;

NAKAMURA, T ;

OHIZUMI, Y .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (10) :2609-2611

[9] KERAMAMIDE-B, KERAMAMIDE-C, AND KERAMAMIDE-D - NOVEL PEPTIDES FROM THE OKINAWAN MARINE SPONGE THEONELLA SP [J].

KOBAYASHI, J ;

ITAGAKI, F ;

SHIGEMORI, H ;

ISHIBASHI, M ;

TAKAHASHI, K ;

OGURA, M ;

NAGASAWA, S ;

NAKAMURA, T ;

HIROTA, H ;

OHTA, T ;

NOZOE, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (20) :7812-7813

[10]

KOBAYASHI M, 1994, CHEM PHARM BULL, V42, P1410