Practical synthesis of tetrasubstituted thiophenes for use in compound libraries

被引：66

作者：

McKibben, BP ^{[1
]}

Cartwright, CH ^{[1
]}

Castelhano, AL ^{[1
]}

机构：

[1] Cadus Pharmaceut Corp, Tarrytown, NY 10591 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(99)01108-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrasubstituted thiophenes, obtained by optimizing the multi-component reaction originally developed by Gewald, served as key templates for structural diversification and semi-automated library synthesis. Conditions were developed to carry out Gewald's reaction at room temperature and in high yield. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：5471 / 5474

页数：4

共 22 条

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[2]

Armstrong Robert W., 1997, P153

[3] Multiple-component condensation strategies for combinatorial library synthesis [J].