Multi-component reactions 13:: Synthesis of γ-lactams as part of a multi-ring system via Ugi-4-centre-3-component reaction

被引：87

作者：

Hanusch-Kompa, C ^{[1
]}

Ugi, I ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, Lehrstuhl 1, D-85747 Garching, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(98)00428-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Preparation of gamma-lactams 2a-h and 4a-h as part of a bi-or tri-cycle system in a one-pot Ugi-4-centre-3-component reaction (U-4C-3CR). A 3-keto or aldo acid was used as bifunctional educt. The application of C-protected amino acids as amine components enables an intramolecular condensation forming 2,6-piperazinediones 5a-h, connected to the gamma-lactam system (1,4-diazabicyclo[4.3.0]nonane-3,5,9-triones). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2725 / 2728

页数：4

共 6 条

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[3] A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams
Short, KM
Mjalli, AMM
[J]. TETRAHEDRON LETTERS, 1997, 38 (03) : 359 - 362
[4] MULTICOMPONENT REACTIONS IN ORGANIC-CHEMISTRY
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[J]. ENDEAVOUR, 1994, 18 (03) : 115 - 122
[5] Ugi I., 1971, Isonitrile chemistry
[6] UGI I, 1997, IN PRESS HETEROCYCLE

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