A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams

被引:91
作者
Short, KM [1 ]
Mjalli, AMM [1 ]
机构
[1] ONTOGEN CORP,CARLSBAD,CA 92009
关键词
D O I
10.1016/S0040-4039(96)02303-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of small-ring lactams via the condensation ol omega-ketoacids, isocyanides and amines is reported This process is shown to proceed well in a combinatorial fashion, by immobilization of the isocyanide component on Wang resin. The product is then released from the support on treatment with 10% TFA/CH2Cl2. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码:359 / 362
页数:4
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