α-Glucosidase inhibitor from Buthus martensi Karsch

被引：64

作者：

Kim, Shin-Duk ^{[1
]}

机构：

[1] Seokyeong Univ, Dept Chem & Biol Engn, Seoul 136704, South Korea

来源：

FOOD CHEMISTRY | 2013年 / 136卷 / 02期

关键词：

alpha-Glucosidase inhibitor; Buthus martensi Karsch; beta-Carboline; Glucopyranoside; Uncompetitive inhibitor;

D O I：

10.1016/j.foodchem.2012.08.063

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

A bioassay-guided fractionation of an ethanol extract of Buthus martensi Karsch led to the isolation of a potent alpha-glucosidase inhibitor (compound S). The structure was elucidated as a novel beta-carboline glucoalkaloid, harmanyl beta-D-glucopyranoside, on the basis of spectral data, including H-1 NMR, C-13 NMR, H-1-H-1 COSY, NOESY, and HMBC. Compound S showed potent inhibitory activity against alpha-glucosidase, with an IC50 value of 24 mu M. A Lineweaver-Burk plot indicated that its inhibition of alpha-glucosidase was uncompetitive, with a Ki value of 16.1 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：297 / 300

页数：4

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