PCL loaded with sol-gel synthesized organic-inorganic hybrid fillers: from the analysis of 2D substrates to the design of 3D rapid prototyped composite scaffolds for tissue engineering

被引：5

作者：

De Santis, R. ^{[1
]}

Gloria, A. ^{[1
]}

Russo, T. ^{[1
]}

D'Amora, U. ^{[1
]}

D'Anto, V. ^{[2
]}

Bollino, F. ^{[3
]}

Catauro, M. ^{[3
]}

Mollica, F. ^{[4
]}

Rengo, S.

Ambrosio, L. ^{[1
]}

机构：

[1] CNR, Inst Composite & Biomed Mat, Ple Tecchio 80, I-80125 Naples, Italy

[2] Univ Naples Federico II, Dept Oral & maxillofocial sci, I-80128 Naples, Italy

[3] Univ Naples Federico II, Dept Mech & Aeronaut Engn, I-81031 Naples, Italy

[4] Univ Ferrara, Dept Engn, I-44122 Ferrara, Italy

来源：

6TH INTERNATIONAL CONFERENCE ON TIMES OF POLYMERS (TOP) AND COMPOSITES | 2012年 / 1459卷

关键词：

Tissue engineering; Composite scaffolds; Organic-inorganic hybrid; Poly(epsilon-caprolactone); Finite element analysis; Alamar Blue (TM) assay; Mechanical properties; DRUG-DELIVERY;

D O I：

10.1063/1.4738387

中图分类号：

TB33 [复合材料];

学科分类号：

080505 [复合材料];

摘要：

As reported in the literature, scaffolds for soft and hard tissue regeneration should satisfy several requirements. In the present work, the potential of 3D fiber deposition technique to design morphologically controlled scaffolds consisting of poly(epsilon-caprolactone) reinforced with sol-gel synthesized organic-inorganic hybrid fillers was demonstrated, also benefiting from a basic study carried out on 2D composite substrates. Finite element analysis, biological and mechanical tests were properly performed to assess the effects of the inclusion of the hybrid fillers on the performances of 2D substrates and 3D structures.

引用

页码：26 / 29

页数：4

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