Effect of beta-endorphin C-terminal peptides on glucose uptake in isolated skeletal muscles of the mouse

被引：9

作者：

Evans, AAL ^{[1
]}

Smith, ME ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT PHYSIOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

PEPTIDES | 1997年 / 18卷 / 01期

关键词：

beta-endorphin C-terminal; skeletal muscle; glucose uptake; insulin; diabetes;

D O I：

10.1016/S0196-9781(96)00241-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The uptake of a nonmetabolizable derivative of glucose, [H-3]2-deoxy-D-glucose, was examined in isolated slow (soleus) and fast (extensor digitorum longus, EDL) muscles of adult mice. An analogue of beta-endorphin(28-31), Ac-Lys-D-Lys-Sar-Glu, which is stable to proteolytic digestion, enhanced the uptake of glucose into the slow and fast muscles. The muscles of male mice were more sensitive to the peptide than those of female mice. The maximum uptake seen in the presence of the peptide was similar to that seen with insulin in the soleus muscle and greater than that seen with insulin in the EDL muscle. (C) 1997 Elsevier Science Inc.

引用

页码：165 / 167

页数：3

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