Hibernation-induction trigger .2. In vitro effects of prairie dog plasma albumin on mouse vas deferens contractility

被引:7
作者
Bruce, DS
Cox, DE
Crane, SK
Denholm, ML
Dhyanchand, RJ
Hampl, MJ
Kary, JA
Krober, AS
Oeltgen, PR
Horton, ND
Harlow, HJ
机构
[1] UNIV KENTUCKY,COLL MED,DEPT PATHOL,LEXINGTON,KY 40536
[2] VET ADM MED CTR,PATHOL SERV,LEXINGTON,KY 40536
[3] UNIV WYOMING,DEPT ZOOL & PHYSIOL,LARAMIE,WY 82070
关键词
hibernation induction trigger; HIT; prairie dog; mouse vas deferens;
D O I
10.1016/S0091-3057(97)00062-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Involvement of opioid molecules in hibernation is well established, with the delta opioid receptor implicated in hibernation induction. Previous studies have shown that plasma albumin fractions (PAFs) from hibernating mammals contain an uncharacterized ligand called ''hibernation-induction trigger'' (HIT), which causes inhibition of induced contractility in the guinea pig ileum (GPI). In part I of this study, we described effects of PAF from two species of prairie dogs on induced contractility of the GPI. In the present study (part II), we examine the response of the mouse vas deferens (MVD), which is populated with the delta receptor subtype, to increasing concentrations of PAF from the white-tailed prairie dog (WT) and the black-tailed prairie dog (BT). Dose-response curves of lyophilized PAF yielded ICS, values (mg) (mean dose that inhibits contractility to 50% of control) of 11.0 for summer WT, 10.6 for hibernating WT, 9.4 for summer BT, 12.2 for winter active BT, and 4.7 for winter hibernating BT. These results suggest that delta opioid (HIT) is present in both species throughout the calendar year and that the induction of hibernation may involve not only levels of opioid but also dynamic interactions between endogenous opioid and its receptors. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:627 / 630
页数:4
相关论文
共 17 条
[1]   SUMMER HIBERNATION INDUCED IN GROUND-SQUIRRELS (CITELLUS-TRIDECEMLINEATUS) BY URINE OR PLASMA FROM HIBERNATING BATS (MYOTIS-LUCIFUGUS OR EPTESICUS-FUSCUS) [J].
BRUCE, DS ;
TUGGY, ML ;
PEARSON, PJ .
CRYOBIOLOGY, 1984, 21 (03) :371-374
[2]   IS THE POLAR BEAR (URSUS-MARITIMUS) A HIBERNATOR - CONTINUED STUDIES ON OPIOIDS AND HIBERNATION [J].
BRUCE, DS ;
DARLING, NK ;
SEELAND, KJ ;
OELTGEN, PR ;
NILEKANI, SP ;
AMSTRUP, SC .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (03) :705-711
[3]   SUPPRESSION OF GUINEA-PIG ILEUM INDUCED CONTRACTILITY BY PLASMA-ALBUMIN OF HIBERNATORS [J].
BRUCE, DS ;
AMBLER, DL ;
HENSCHEL, TM ;
OELTGEN, PR ;
NILEKANI, SP ;
AMSTRUP, SC .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1992, 43 (01) :199-203
[4]   Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum [J].
Bruce, DS ;
Bailey, EC ;
Setran, DP ;
Tramell, MS ;
Jacobson, D ;
Oeltgen, PR ;
Horton, ND ;
Hellgren, EC .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 53 (04) :885-889
[5]   OPIOIDS AND HIBERNATION .1. EFFECTS OF NALOXONE ON BEAR HITS DEPRESSION OF GUINEA-PIG ILEUM CONTRACTILITY AND ON INDUCTION OF SUMMER HIBERNATION IN THE GROUND-SQUIRREL [J].
BRUCE, DS ;
COPE, GW ;
ELAM, TR ;
RUIT, KA ;
OELTGEN, PR ;
SU, TP .
LIFE SCIENCES, 1987, 41 (18) :2107-2113
[6]  
BRUCE DS, IN PRESS PHARM BIOCH
[7]   HIBERNATION INDUCED IN GROUND SQUIRRELS BY BLOOD TRANSFUSION [J].
DAWE, AR ;
SPURRIER, WA .
SCIENCE, 1969, 163 (3864) :298-&
[8]   SUMMER HIBERNATION INDUCED BY CRYOGENICALLY PRESERVED BLOOD TRIGGER [J].
DAWE, AR ;
SPURRIER, WA ;
ARMOUR, JA .
SCIENCE, 1970, 168 (3930) :497-&
[9]  
FRANK CL, UNPUB CAN J ZOOL
[10]   KIDNEY STRUCTURE AND FUNCTION OF OBLIGATE AND FACULTATIVE HIBERNATORS - THE WHITE-TAILED PRAIRIE DOG (CYNOMYS LEUCURUS) AND THE BLACK-TAILED PRAIRIE DOG (CYNOMYS-LUDOVICIANUS) [J].
HARLOW, HJ ;
BRAUN, EJ .
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 1995, 165 (04) :320-328