Molecular chaperones and disease

被引：21

作者：

Henderson, B ^{[1
]}

Nair, SP ^{[1
]}

Coates, ARM ^{[1
]}

机构：

[1] ST GEORGE HOSP, SCH MED, DEPT CELLULAR & MOLEC SCI, DIV MOL MICROBIOL, LONDON SW17 0RE, ENGLAND

来源：

INFLAMMATION RESEARCH | 1996年 / 45卷 / 04期

关键词：

molecular chaperones; therapy; heatshock proteins disease; cytokines;

D O I：

10.1007/BF02285154

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Molecular chaperones are intracellular protein-folding proteins which form part of an ancient cellular response to stress called the heat shock response. They have been the focus for attention during the last decade because of the discovery of their vital role in cell functioning. In very recent years additional roles for these 'topologically-active' proteins in the process of tissue pathology and its treatment have been indicated and are reviewed.

引用

页码：155 / 158

页数：4

共 51 条

[1] A FATAL, SYSTEMIC MITOCHONDRIAL DISEASE WITH DECREASED MITOCHONDRIAL ENZYME-ACTIVITIES, ABNORMAL ULTRASTRUCTURE OF THE MITOCHONDRIA AND DEFICIENCY OF HEAT-SHOCK PROTEIN-60 [J].

AGSTERIBBE, E ;

HUCKRIEDE, A ;

VEENHUIS, M ;

RUITERS, MHJ ;

NIEZENKONING, KE ;

SKJELDAL, OH ;

SKULLERUD, K ;

GUPTA, RS ;

HALLBERG, R ;

VANDIGGELEN, OP ;

SCHOLTE, HR .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 193 (01) :146-154

[2] HEAT-SHOCK PROTEINS INDUCE PORES IN MEMBRANES [J].

ALDER, GM ;

AUSTEN, BM ;

BASHFORD, CL ;

MEHLERT, A ;

PASTERNAK, CA .

BIOSCIENCE REPORTS, 1990, 10 (06) :509-518

[3]

ANDERTON SM, 1994, J IMMUNOL, V152, P3656

[4]

BAKAU B, 1993, MOL MICROBIOL, V9, P671

[5] THE MYCOBACTERIUM-TUBERCULOSIS 71-KDA HEAT-SHOCK PROTEIN INDUCES PROLIFERATION AND CYTOKINE SECRETION BY MURINE GUT INTRAEPITHELIAL LYMPHOCYTES [J].

BEAGLEY, KW ;

FUJIHASHI, K ;

BLACK, CA ;

LAGOO, AS ;

YAMAMOTO, M ;

MCGHEE, JR ;

KIYONO, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (08) :2049-2052

[6] HEAT-SHOCK PROTEIN VACCINES AGAINST CANCER [J].

BLACHERE, NE ;

UDONO, H ;

JANETZKI, S ;

LI, ZH ;

HEIKE, M ;

SRIVASTAVA, PK .

JOURNAL OF IMMUNOTHERAPY, 1993, 14 (04) :352-356

[7] THE PURIFICATION OF EARLY-PREGNANCY FACTOR TO HOMOGENEITY FROM HUMAN PLATELETS AND IDENTIFICATION AS CHAPERONIN-10 [J].

CAVANAGH, AC ;

MORTON, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 222 (02) :551-560

[8]

COATES ARM, 1996, CHAPERONINS

[9] MUTATIONS OF THE HEAT INDUCIBLE 70-KILODALTON GENES OF YEAST CONFER TEMPERATURE SENSITIVE GROWTH [J].

CRAIG, EA ;

JACOBSEN, K .

CELL, 1984, 38 (03) :841-849

[10] HEAT-SHOCK RESPONSE AND LIMITATION OF TISSUE NECROSIS DURING OCCLUSION REPERFUSION IN RABBIT HEARTS [J].

CURRIE, RW ;

TANGUAY, RM ;

KINGMA, JG .

CIRCULATION, 1993, 87 (03) :963-971

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