HEAT-SHOCK PROTEINS INDUCE PORES IN MEMBRANES

被引：41

作者：

ALDER, GM

AUSTEN, BM

BASHFORD, CL

MEHLERT, A

PASTERNAK, CA

机构：

[1] ST GEORGE HOSP,SCH MED,DEPT CELLULAR & MOLEC SCI,LONDON SW17 0RE,ENGLAND

[2] ST GEORGE HOSP,SCH MED,DEPT SURG,LONDON SW17 0RE,ENGLAND

[3] UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND

来源：

BIOSCIENCE REPORTS | 1990年 / 10卷 / 06期

关键词：

HEAT SHOCK PROTEINS; MEMBRANES; PORES;

D O I：

10.1007/BF01116611

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human heat shock protein (hsp) 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide, by S. aureus alpha toxin or by diphtheria toxin. Hsp 70 and groEL, as well as two mycobacterial homologues hsp 71 and hsp 65, induce ion conducting pores across planar lipid bilayers at low or neutral pH. It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells.

引用

页码：509 / 518

页数：10

共 43 条

[1] ACTION OF DIPHTHERIA-TOXIN DOES NOT DEPEND ON THE INDUCTION OF LARGE, STABLE PORES ACROSS BIOLOGICAL-MEMBRANES [J].