The dynamics of dendritic cell-T cell interactions in priming and tolerance

被引:39
作者
Hugues, Stephanie
Boissonnas, Alexandre
Amigorena, Sebastian
Fetler, Luc
机构
[1] CNRS, UMR 168, Chim Phys Lab, Inst Curie, F-75245 Paris 05, France
[2] INSERM, U653, Inst Curie, F-75245 Paris 05, France
关键词
D O I
10.1016/j.coi.2006.03.021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Induction of T cell priming and tolerance require direct encounters between naive T cells and dendritic cells (DCs). T cell activation and proliferation occur in both situations, but the concomitant dynamics of DC-T cell contacts differ: the contacts between naive T cells and DCs are more stable during the induction of priming than during the induction of tolerance. However, the extent of the differences between the dynamics of the contacts, and the contribution of contact duration and frequency to the functional T cell outcome, remain a matter of debate. Recently, experimental models have been developed to address the role of contact stability in T cell function in vivo, which use real-time imaging of DC-T cell interactions.
引用
收藏
页码:491 / 495
页数:5
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