Signal Transduction by Vascular Endothelial Growth Factor Receptors

被引：703

作者：

Koch, Sina ^{[1
]}

Claesson-Welsh, Lena ^{[1
]}

机构：

[1] Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, S-75185 Uppsala, Sweden

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2012年 / 2卷 / 07期

关键词：

FOCAL ADHESION KINASE; NITRIC-OXIDE SYNTHASE; TYROSINE PHOSPHORYLATION SITES; VEGF-INDUCED ANGIOGENESIS; PHOSPHOLIPASE-C-GAMMA; CELL-MIGRATION; TUMOR ANGIOGENESIS; ADAPTER PROTEIN; HEREDITARY LYMPHEDEMA; EXTRACELLULAR-MATRIX;

D O I：

10.1101/cshperspect.a006502

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs). In addition, coreceptors like neuropilins (NRPs) and integrins associate with the ligand/receptor signaling complex and modulate the output. Therapeutics to block several of the VEGF signaling components have been developed with the aim to halt blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. In this review, we outline the current information on VEGF signal transduction in relation to blood and lymphatic vessel biology.

引用

页数：21

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