New descriptors of T-wave morphology are independent of heart rate

被引：58

作者：

Andersen, Mads P. ^{[1
]}

Xue, Joel Q. ^{[2
]}

Graff, Claus ^{[1
]}

Kanters, Jorgen K. ^{[3
,4
]}

Toft, Egon ^{[1
]}

Struijk, Johannes J. ^{[1
]}

机构：

[1] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

[2] GE Healthcare, Diagnost Cardiol, Milwaukee, WI USA

[3] Gentofte Univ Hosp, Dept Cardiol, Copenhagen, Denmark

[4] Univ Copenhagen, Ctr Cardiac Arrhythmia, Copenhagen, Denmark

来源：

JOURNAL OF ELECTROCARDIOLOGY | 2008年 / 41卷 / 06期

关键词：

Repolarization; Electrocardiography; QT; RR; Drug safety; T-wave morphology; Heart rate dependence;

D O I：

10.1016/j.jelectrocard.2008.07.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holier recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R-2 = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R-2 = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R-2 = 0-0.08), making heart rate correction unnecessary for these parameters. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：557 / 561

页数：5

共 19 条

[1] A Robust Method for Quantification of IKr-Related T-Wave Morphology Abnormalities [J].