Frontal signal hyperintensities in mania in old age

被引:21
作者
de Asis, Jose M.
Greenwald, Blaine S.
Alexopoulos, George S.
Kiosses, Dimitris N.
Ashtari, Manzar
Heo, Moonseong
Young, Robert C.
机构
[1] Cornell Univ, Westchester Div, NY Presbyterian Hosp, Coll Med,Dept Psychiat, White Plains, NY 10605 USA
[2] Long Isl Jewish Med Ctr, Hillside Hosp, Div Psychiat, Dept Psychiat, Glen Oaks, NY 11004 USA
关键词
geriatric mania; signal hyperintensities; MRI; illness onset;
D O I
10.1097/01.JGP.0000200603.70504.d5
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: Signal hyperintensities (SH) on magnetic resonance (MR) imaging have been associated with increased age and with mood disorders. Frontal and subcortical neuropathology has been implicated in the pathophysiology of mania and bipolar disorders. The authors assessed frontal and subcortical SH in elderly bipolar manic patients and the comparison group, and hypothesized that SH scores would be greater in the patient group. Method: MR imaging was performed in patients aged >= 60 years with bipolar disorder, mania, and in a same-aged community comparison group. SH were rated blindly using the Boyko system. Frontal deep white matter and basal ganglia SH were assessed in the left and right hemispheres. Results: SH scores were significantly greater in patients (N = 40) than the comparison group (N = 15) in frontal deep white matter (left: p = 0.003; right: p = 0.023) based on Mann-Whitney two-sample exact tests. The SH scores in the subcortical gray regions overlapped in these groups. In patients, higher right frontal SH scores were associated with later age at onset of mania. Conclusions: Frontal deep white matter SH may be increased in elders with bipolar disorder. Further study of the relationship of SH to age at onset in elders is warranted.
引用
收藏
页码:598 / 604
页数:7
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