Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance

被引：34

作者：

Aredia, Francesca ^{[1
,2
]}

Scovassi, A. Ivana ^{[2
]}

机构：

[1] Ist Genet Molecolare CNR, I-27100 Pavia, Italy

[2] CNR, Ist Genet Mol, I-27100 Pavia, Italy

来源：

FUTURE MEDICINAL CHEMISTRY | 2013年 / 5卷 / 09期

关键词：

CASPASE-MEDIATED CLEAVAGE; TARGETING AUTOPHAGY; SIGNALING PATHWAYS; THERAPEUTIC TARGET; MAMMALIAN TARGET; MTOR INHIBITORS; DOWN-REGULATION; TUMOR-CELLS; DUAL ROLE; BECLIN;

D O I：

10.4155/fmc.13.85

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Autophagy is a catabolic process activated by stress conditions and nutrient deprivation, to which it reacts by promoting the degradation of damaged organelles and misfolded/aggregated proteins, as well as generating new energetic pools. Paradoxically, in cancer cells, which signal the dangerous microenvironment occurring during clinical therapies, autophagy could promote their proliferation and sustain drug resistance. Special attention is given to autophagy manipulation in order to counteract drug resistance of cancer cells. This article describes the basic properties of autophagy and focuses on the strategies of manipulating it.

引用

页码：1009 / 1021

页数：13

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