Anti-leukemia effect of resveratrol

被引：48

作者：

Tsan, MF ^{[1
]}

White, JE ^{[1
]}

Maheshwari, JG ^{[1
]}

Chikkappa, G ^{[1
]}

机构：

[1] Dept Vet Affairs, Reg Off 10R, Off Res Compliance & Assurance, Washington, DC 20422 USA

来源：

LEUKEMIA & LYMPHOMA | 2002年 / 43卷 / 05期

关键词：

resveratrol; leukemia; apoptosis;

D O I：

10.1080/10428190290021669

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resveratrol is a phytoalexin naturally present in fruits, medicinal plants and wines. It has a diversity of biological activities. While its role in the protection against coronary heart disease (CHD) in people with moderate wine consumption, remains unclear, resveratrol preferentially inhibits the growth of leukemia cells in culture. Potential mechanisms for its anti-leukemia effect include induction of leukemia cell differentiation, apoptosis, and cell cycle arrest at S-phase and inhibition of DNA synthesis by inhibiting ribonucleotide reductase or DNA polymerase. Preliminary results suggest that resveratrol also inhibits the viability of freshly isolated leukemia cells, especially promyelocytic leukemia cells. Because of its low in vivo toxicity, resveratrol deserves further investigation as an antileukemia agent.

引用

页码：983 / 987

页数：5

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