Analgesic and antiinflammatory activities of the ethyl acetate fraction of Bidens pilosa (Asteraceae)

被引：35

作者：

Fotso, Aurelien ^{[1
]}

Longo, Frida ^{[1
]}

Djomeni, Paul Desire Dzeufiet ^{[2
]}

Kouam, Simeon Fogue ^{[3
]}

Spiteller, Michael ^{[4
]}

Dongmo, Alain Bertrand ^{[5
]}

Savineau, J. P. ^{[6
]}

机构：

[1] Univ Yaounde I, Dept Biol Sci, Higher Teachers Training Coll, Physiol Anim Lab, Yaounde, Cameroon

[2] Univ Yaounde I, Dept Anim Biol & Physiol, Physiol Anim Lab, Fac Sci, Yaounde, Cameroon

[3] Univ Yaounde I, Dept Chem, Higher Teachers Training Coll, Organ Chem Lab, Yaounde, Cameroon

[4] TU Dortmund, Inst Environm Res INFU, Fac Chem, D-44221 Dortmund, Germany

[5] Univ Douala, Lab Anim Organism Biol, Fac Sci, Douala, Cameroon

[6] Univ Bordeaux 2, Cardiothorax Res Ctr Bordeaux, INSERM, U1045, F-33076 Bordeaux, France

来源：

INFLAMMOPHARMACOLOGY | 2014年 / 22卷 / 02期

关键词：

Bidens pilosa; Analgesic; Antiinflammatory; Flavonoids; METHYLENE-CHLORIDE EXTRACTS; STEM BARK; FLAVONOIDS; MORPHINE; METHANOL; LEAVES; EDEMA; PAIN; RAT; PAW;

D O I：

10.1007/s10787-013-0196-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Bidens pilosa is an Asteraceae widely used in traditional medicine for the treatment of various ailments including pain and inflammation. The present work was undertaken to assess the analgesic and antiinflammatory properties of the ethyl acetate fraction of methylene chloride/methanol (1:1) extract of leaves of Bidens pilosa at the gradual doses of 50, 100 and 200 mg/kg in mice and rats, respectively. The analgesic properties of Bidens pilosa were investigated using the acetic acid writhing, hot plate, capsaicin and formalin-induced pain models. This was followed by a study of the antiinflammatory properties using carrageenan, dextran, histamine and serotonin to induce acute inflammation in rat hind paw. The extract provided a significant (p < 0.01) reduction in pain induced by all four models of nociception. It also presented significant (p < 0.05) antiinflammatory activity in all four models of acute inflammation. These results show that the ethyl acetate fraction of methylene chloride/methanol (1:1) of Bidens pilosa has both analgesic and antiinflammatory properties. The qualitative analysis of the fraction by the high-performance liquid chromatography (HPLC) fingerprint revealed the presence of two flavonoids, namely quercetin and iso-okanin, known to have antiinflammatory and antinociceptive properties, which could be responsible for the analgesic and antiinflammatory effects observed.

引用

页码：105 / 114

页数：10

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