An HPLC method for the determination of vitamin B1, caffeine, acetylsalicylic acid, and the impurities of salicylic acid in a pharmaceutical preparation

被引：16

作者：

GamizGracia, L

deCastro, MDL

机构：

[1] Department of Analytical Chemistry, Faculty of Sciences, University of Córdoba

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 1997年 / 20卷 / 13期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; DEXTROPROPOXYPHENE NAPSYLATE; ASPIRIN; ACETAMINOPHEN; SET;

D O I：

10.1080/10826079708005570

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An HPLC method for the determination of Vitamin B1, caffeine, acetylsalicylic acid and salicylic acid in tablets containing all four drugs is reported. After optimization of the variables involved, the method has been characterized and validated in terms of calibration (Standard Addition Methodology), repeatability and selectivity, and finally, applied to the quality control of the final product.

引用

页码：2123 / 2133

页数：11

共 13 条

[1]

ABUIRJEIE MA, 1989, ANAL LETT, V22, P365

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF WATER-SOLUBLE VITAMINS .2. SIMULTANEOUS DETERMINATIONS OF VITAMIN-B1 VITAMIN-B2, VITAMIN-B6, AND VITAMIN-B12 IN PHARMACEUTICAL PREPARATIONS [J].