Virus smuggling, tax evasion and tumor assassination

被引：9

作者：

Harrington, K ^{[1
]}

Vile, R

机构：

[1] Inst Canc Res, London SW3, England

[2] Mayo Clin, Coll Med, Dept Immunol, Rochester, MN 55902 USA

[3] Mayo Clin, Coll Med, Program Mol Med, Rochester, MN 55902 USA

来源：

NATURE MEDICINE | 2006年 / 12卷 / 05期

关键词：

D O I：

10.1038/nm0506-507

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A new approach to killing tumors combines two methods that each alone have shortcomings. A tumor-killing virus is loaded into a cell type that homes to tumors, thereby evading the antiviral immune response.

引用

页码：507 / 509

页数：4

共 15 条

[1]

Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells [J].

Cole, C ;

Qiao, J ;

Kottke, T ;

Diaz, RM ;

Ahmed, A ;

Sanchez-Perez, L ;

Brunn, G ;

Thompson, J ;

Chester, J ;

Vile, RG .

NATURE MEDICINE, 2005, 11 (10) :1073-1081

[2]

Adoptive-cell-transfer therapy for the treatment of patients with cancer [J].

Dudley, ME ;

Rosenberg, SA .

NATURE REVIEWS CANCER, 2003, 3 (09) :666-U2

[3]

Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model [J].

Gómez-Navarro, J ;

Contreras, JL ;

Arafat, W ;

Jiang, XL ;

Krisky, D ;

Oligino, T ;

Marconi, P ;

Hubbard, B ;

Glorioso, JC ;

Curiel, DT ;

Thomas, JM .

GENE THERAPY, 2000, 7 (01) :43-52

[4]

The macrophage - a novel system to deliver gene therapy to pathological hypoxia [J].

Griffiths, L ;

Binley, K ;

Iqball, S ;

Kan, O ;

Maxwell, P ;

Ratcliffe, P ;

Lewis, C ;

Harris, A ;

Kingsman, S ;

Naylor, S .

GENE THERAPY, 2000, 7 (03) :255-262

[5]

Cells as vehicles for cancer gene therapy: The missing link between targeted vectors and systemic delivery? [J].

Harrington, K ;

Alvarez-Vallina, L ;

Crittenden, M ;

Gough, M ;

Chong, H ;

Diaz, RM ;

Vassaux, G ;

Lemoine, N ;

Vile, R .

HUMAN GENE THERAPY, 2002, 13 (11) :1263-1280

[6]

Use of blood outgrowth endothelial cells as virus-producing vectors for gene delivery to tumors [J].

Jevremovic, D ;

Gulati, R ;

Hennig, I ;

Diaz, RM ;

Cole, C ;

Kleppe, L ;

Cosset, FL ;

Simari, RD ;

Vile, RG .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (02) :H494-H500

[7]

Replication-selective virotherapy for cancer: Biological principles, risk management and future directions [J].

Kirn, D ;

Martuza, RL ;

Zwiebel, J .

NATURE MEDICINE, 2001, 7 (07) :781-787

[8]

A phase I trial of autologous cytokine-induced killer cells for the treatment of relapsed Hodgkin disease and non-Hodgkin lymphoma [J].

Leemhuis, T ;

Wells, S ;

Scheffold, C ;

Edinger, M ;

Negrin, RS .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2005, 11 (03) :181-187

[9]

LU PH, 1994, J IMMUNOL, V153, P1687

[10]

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth [J].

Lyden, D ;

Hattori, K ;

Dias, S ;

Costa, C ;

Blaikie, P ;

Butros, L ;

Chadburn, A ;

Heissig, B ;

Marks, W ;

Witte, L ;

Wu, Y ;

Hicklin, D ;

Zhu, ZP ;

Hackett, NR ;

Crystal, RG ;

Moore, MAS ;

Hajjar, KA ;

Manova, K ;

Benezra, R ;

Rafii, S .

NATURE MEDICINE, 2001, 7 (11) :1194-1201

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