Endothelium and Its Alterations in Cardiovascular Diseases: Life Style Intervention

被引:209
作者
Favero, Gaia [1 ]
Paganelli, Corrado [2 ]
Buffoli, Barbara [1 ]
Rodella, Luigi Fabrizio [1 ]
Rezzani, Rita [1 ]
机构
[1] Univ Brescia, Sect Anat & Physiopathol, Dept Clin & Expt Sci, I-25123 Brescia, Italy
[2] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, I-25123 Brescia, Italy
关键词
NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; PERIVASCULAR ADIPOSE-TISSUE; VIRGIN OLIVE OIL; RED WINE CONSUMPTION; MUSCLE RESISTANCE ARTERIES; TRANS-FATTY-ACIDS; PROGENITOR CELLS; OXIDATIVE STRESS; MESSENGER-RNA;
D O I
10.1155/2014/801896
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a highly metabolically active organ that is involved in many physiopathological processes, including the control of vasomotor tone, barrier function, leukocyte adhesion, and trafficking and inflammation. In this review, we summarized and described the following: (i) endothelial cell function in physiological conditions and (ii) endothelial cell activation and dysfunction in the main cardiovascular diseases (such as atherosclerosis, and hypertension) and to diabetes, cigarette smoking, and aging physiological process. Finally, we presented the currently available evidence that supports the beneficial effects of physical activity and various dietary compounds on endothelial functions.
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页数:28
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