Persistent neuroinvasive West Nile Virus infection in an immunocompromised patient

被引：63

作者：

Penn, RG

Guarner, J

Sejvar, JJ

Hartman, H

McComb, RD

Nevins, DL

Bhatnagar, J

Zaki, SR

机构：

[1] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Natl Ctr Infect Dis, Atlanta, GA 30333 USA

[2] Univ Nebraska, Med Ctr, Dept Epidemiol, Methodist Hosp, Omaha, NE 68182 USA

[3] Univ Nebraska, Med Ctr, Dept Med, Methodist Hosp, Omaha, NE 68182 USA

[4] Univ Nebraska, Med Ctr, Dept Pathol, Methodist Hosp, Omaha, NE 68182 USA

[5] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68182 USA

[6] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Natl Ctr Infect Dis, Ft Collins, CO USA

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 42卷 / 05期

关键词：

D O I：

10.1086/500216

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 57-year-old man who had received treatment for B cell lymphoma presented with West Nile virus (WNV) meningoencephalitis. During his 99-day hospitalization, no WNV-specific antibodies were detected. In postmortem central nervous system samples obtained at autopsy, WNV RNA and WNV antigens were detected. This patient's case raises important issues related to the diagnosis, pathogenesis, and possible treatment of persistent WNV infection.

引用

页码：680 / 683

页数：4

共 14 条

[1] Prophylactic and therapeutic efficacy of human intravenous immunoglobulin in treating West Nile virus infection in mice [J].