Structural e-bioinformatics and drug design

被引：8

作者：

Carpy, AJM ^{[1
]}

Marchand-Geneste, N ^{[1
]}

机构：

[1] Univ Bordeaux 1, CNRS, UMR 5472, Lab Physico & Toxicochim Syst Nat, F-33405 Talence, France

来源：

SAR AND QSAR IN ENVIRONMENTAL RESEARCH | 2006年 / 17卷 / 01期

关键词：

Internet; bioinformatics; database searching; sequence hornology; docking; drug design;

D O I：

10.1080/10659360600560966

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nowadays the in silico scenario for drug design is totally dependent on structural biology and structural bioinformatics. A myriad of free bioinformatics applications and services have been posted on the web. This mini-review mentions web sites that are useful in structure-based drug design. The information is given in a logical manner, following the drug design process i.e. characterization of a protein target, modelling the protein using sequence homology, optimization of the protein structure and finally docking of small ligands into the active site.

引用

页码：1 / 10

页数：10