Cytotoxicity and in-vivo tolerance of FdUMP[10]: A novel pro-drug of the TS inhibitory nucleotide FdUMP

被引：13

作者：

Gmeiner, WH ^{[1
]}

Skradis, A

Pon, RT

Liu, JQ

机构：

[1] Univ Nebraska, Med Ctr, Eppley Inst, Omaha, NE 68198 USA

[2] Univ Nebraska, Med Ctr, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[3] Univ Calgary, Core DNA Synth Facil, Calgary, AB T2N 1N4, Canada

来源：

NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 6-7期

关键词：

D O I：

10.1080/07328319908044836

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxicity of the 10mer ODN FdUMP[10] towards human colorectal tumor cells was evaluated using a clonogenic assay. FdUMP[10] was more than 100-fold more active than 5-FU at inhibiting colony formation of H630 cells. FdUMP[10] was also evaluated for cytotoxicity in the NCI 60 cell line screen, and showed markedly improved activity relative to 5-FU against numerous tumor cell lines. The in-vivo tolerance of FdUMP[10] is more than three-fold greater per mole fluorinated pyrimidine, than 5-FU.

引用

页码：1729 / 1730

页数：2