Mechanical Features of Plasmodium falciparum Acyl Carrier Protein in the Delivery of Substrates

被引：15

作者：

Colizzi, Francesco ^{[1
]}

Recanatini, Maurizio ^{[1
]}

Cavalli, Andrea ^{[1
,2
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Italian Inst Technol, Dept Drug Discovery & Dev, I-16163 Genoa, Italy

来源：

JOURNAL OF CHEMICAL INFORMATION AND MODELING | 2008年 / 48卷 / 12期

关键词：

D O I：

10.1021/ci800297v

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Acyl Carrier Protein (ACP) is a key element in the biosynthesis of fatty acids being responsible for the acyl group shuttling and delivery within a series of related enzymes. The molecular mechanism of the delivery process is poorly known, and its characterization is essential for indepth Understanding the biosynthetic machinery. A steered molecular dynamics approach has been applied to shed light oil the putative delivery pathway, suggesting the small alpha 3- helix act as gatekeeper for the transfer process. Preventing the delivery mechanism Would be an innovative strategy for the development of pathway-based antimalarial compounds.

引用

页码：2289 / 2293

页数：5

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