In vitro activities of a new des-fluoroquinolone, BMS 284756, and seven other antimicrobial agents against 151 isolates of Eikenella corrodens

The des-fluoroquinolone BMS 284756 was active in vitro against all 151 clinical strains of Eikenella corrodens at a MIC of less than or equal to0.25 mug/ml and was comparable in activity to moxilloxacin and levofloxacin. The MIC at which 90% of the isolates were inhibited by penicillin G was 2 mug/ml; MICs for 8.6% of the strains (13 of 151) were greater than or equal to4 mug/ml, including for two beta-lactamase-producing isolates. Amoxicillin-clavulanate and ampicillin-sulbactam inhibited all strains at a MIC of less than or equal to1 mug/ml.