Protocadherin 15 (PCDH15): a new secreted isoformand a potential marker for NK/T cell lymphomas

被引：22

作者：

Rouget-Quermalet, V

Giustiniani, J

Marie-Cardine, A

Beaud, G

Besnard, F

Loyaux, D

Ferrara, P

Leroy, K

Shimizu, N

Gaulard, P

Bensussan, A

Schmitt, C

机构：

[1] INSERM, Fac Med, U659, F-94010 Creteil, France

[2] Sanofi Aventis, Rueil Malmaison, France

[3] Sanofi Aventis, Labege, France

[4] CHU Henri Mondor, Dept Pathol, INSERM, U 617,AP HP, F-94010 Creteil, France

[5] Med Res Inst, Dept Virol, Tokyo, Japan

来源：

ONCOGENE | 2006年 / 25卷 / 19期

关键词：

NK/T lymphomas; isoforms; PCDH15; RT-PCR;

D O I：

10.1038/sj.onc.1209301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural killer cells are well known to play an important role in immune defense against tumor development and viral infections. To further characterize new functionally relevant structures in these cells, we studied a series of monoclonal antibodies that we have raised against the NK cell line YT. One of these antibodies previously described as AY19, recognizes a 85 kD surface glycoprotein. Here we report the identification of a new secreted isoform of protocadherin 15, PCDH15C, which represents a potential associated protein for p85. Importantly, whereas protocadherins are absent from the surface of normal hematopoietic cells, we describe, for the first time, that PCDH15 is expressed in cytotoxic tumor-derived T- and NK-cell lines as well as in biopsies of nasal NK/T-cell lymphomas.

引用

收藏

页码：2807 / 2811

页数：5

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