A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegratioxn

被引：237

作者：

Bai, Long ^{[1
,2
,3
]}

Du, Zhibin ^{[2
,3
]}

Du, Jingjing ^{[4
]}

Yao, Wei ^{[5
]}

Zhang, Jiaming ^{[1
]}

Weng, Zeming ^{[1
]}

Liu, Si ^{[1
]}

Zhao, Ya ^{[1
]}

Liu, Yanlian ^{[1
]}

Zhang, Xiangyu ^{[1
]}

Huang, Xiaobo ^{[1
]}

Yao, Xiaohong ^{[1
]}

Crawford, Ross ^{[2
,3
]}

Hang, Ruiqiang ^{[1
]}

Huang, Di ^{[4
]}

Tang, Bin ^{[1
]}

Xiao, Yin ^{[2
,3
]}

机构：

[1] Taiyuan Univ Technol, Res Inst Surface Engn, Taiyuan, Shanxi, Peoples R China

[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4059, Australia

[3] Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, Brisbane, Qld 4059, Australia

[4] Taiyuan Univ Technol, Dept Biomed Engn, Coll Mech, Res Ctr Nanobiomat & Regenerat Med, Taiyuan, Shanxi, Peoples R China

[5] Shanxi Med Univ, Coll & Hosp Stomatol, Taiyuan, Shanxi, Peoples R China

来源：

BIOMATERIALS | 2018年 / 162卷

基金：

中国国家自然科学基金;

关键词：

Titanium surface modification; Osteogenesis; Angiogenesis; Osteoimmunomodulation; Osseointegration; NITRIC-OXIDE SYNTHASE; OSTEOBLAST DIFFERENTIATION; CALCIUM-PHOSPHATE; ENDOTHELIAL-CELLS; BONE-FORMATION; TI IMPLANTS; ANGIOGENESIS; OXIDATION; MECHANISMS; BEHAVIOR;

D O I：

10.1016/j.biomaterials.2018.02.010

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

A multifaceted coating for hard tissue implants, with favorable osteogenesis, angiogenesis, and osteoimmunomodulation abilities, would be of great value since it could improve osseointegration and alleviate prosthesis loosening. However, to date there are few coatings that fully satisfy these criteria. Herein we describe a microporous TiO2 coating decorated with hydroxyapatite (HA) nanoparticles that is generated by micro-arc oxidation of pure titanium (Ti) and followed annealing. By altering the annealing temperature, it is possible to simultaneously tune the coating's physical (morphology and wettability) and chemical (composites and crystallinity) properties. A coating produced with micro-arc oxidization (MAO) with an annealing temperature of 650 degrees C (MAO-650) exhibits numerous favorable physicochemical properties, such as hybrid micro-nano morphology, superhydrophilicity, and highly crystalline HA nanoparticles. In vitro experiments reveal that the MAO-650 coating not only supports proliferation and differentiation of both osteoblasts and endothelial cells, but also inhibits the inflammatory response of macrophages and enables a favorable osteoimmunomodulation to facilitate osteo/angio-genesis. In vivo evaluation mirrors these results, and shows that the MAO-650 coating results in ameliorative osseointegration when compared with the pristine MAO coating. These data highlight the profound effect of surface physicochemical properties on the regulation of osteo/angio-genesis and osteoimmunomodulation in the enhancement of osseointegration. Crown Copyright (C) 2018 Published by Elsevier Ltd. All rights reserved.

引用

页码：154 / 169

页数：16

共 84 条

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Third-generation biomedical materials [J].