Big bottlenecks in cardiovascular tissue engineering

被引：70

作者：

Huang, Ngan F. ^{[1
,2
,3
]}

Serpooshan, Vahid ^{[1
,4
,5
,6
]}

Morris, Viola B. ^{[4
,5
,7
]}

Sayed, Nazish ^{[1
]}

Pardon, Gaspard ^{[1
,8
]}

Abilez, Oscar J. ^{[1
,13
]}

Nakayama, Karina H. ^{[1
,2
,3
]}

Pruitt, Beth L. ^{[1
,8
,9
,10
,11
,12
]}

Wu, Sean M. ^{[1
,13
,14
]}

Yoon, Young-sup ^{[4
,5
,7
]}

Zhang, Jianyi ^{[15
]}

Wu, Joseph C. ^{[1
,13
,14
]}

机构：

[1] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA

[3] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA

[4] Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA

[5] Georgia Inst Technol, Atlanta, GA 30332 USA

[6] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30307 USA

[7] Emory Univ, Div Cardiol, Dept Med, Atlanta, GA 30307 USA

[8] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[9] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

[10] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA

[11] Univ Calif Santa Barbara, Dept BioMol Sci & Engn, Santa Barbara, CA 93106 USA

[12] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

[13] Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA

[14] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

[15] Univ Alabama Birmingham, Sch Med, Dept Bioengn, Birmingham, AL 35294 USA

来源：

COMMUNICATIONS BIOLOGY | 2018年 / 1卷

基金：

美国国家卫生研究院;

关键词：

PLURIPOTENT STEM-CELLS; MYOCARDIAL-INFARCTION; DIFFERENTIATION; CARDIOMYOCYTES; SCAFFOLDS; CULTURE;

D O I：

10.1038/s42003-018-0202-8

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

引用

页数：4

共 47 条

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Electrophysiologic Characterization of Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Atrial Cardiomyocytes [J].