Changes in Gene Expression Profiling of Apoptotic Genes in Neuroblastoma Cell Lines upon Retinoic Acid Treatment

被引：17

作者：

Celay, Jon ^{[1
]}

Blanco, Idoia ^{[1
]}

Lazcoz, Paula ^{[1
]}

Rotinen, Mirja ^{[1
]}

Castresana, Javier S. ^{[2
]}

Enci, Ignacio ^{[1
]}

机构：

[1] Univ Publ Navarra, Dept Hlth Sci, Pamplona, Spain

[2] Univ Navarra, Brain Tumor Biol Unit, Sch Sci, E-31080 Pamplona, Spain

来源：

PLOS ONE | 2013年 / 8卷 / 05期

关键词：

NF-KAPPA-B; CHILDRENS ONCOLOGY GROUP; INDUCED DIFFERENTIATION; MYELOABLATIVE THERAPY; 13-CIS-RETINOIC ACID; NUCLEAR-FACTOR; ACTIVATION; PROTEIN; 9-CIS; INHIBITOR;

D O I：

10.1371/journal.pone.0062771

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

To determine the effect of retinoic acid (RA) in neuroblastoma we treated RA sensitive neuroblastoma cell lines with 9-cis RA or ATRA for 9 days, or for 5 days followed by absence of RA for another 4 days. Both isomers induced apoptosis and reduced cell density as a result of cell differentiation and/or apoptosis. Flow cytometry revealed that 9-cis RA induced apoptosis more effectively than ATRA. The expression profile of apoptosis and survival pathways was cell line specific and depended on the isomer used.

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页数：15

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