Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa

被引：56

作者：

Wang, Xiao-Xia ^{[1
,2
]}

Zan, Ke ^{[2
]}

Shi, She-Po ^{[3
]}

Zeng, Ke-Wu ^{[2
]}

Jiang, Yong ^{[2
]}

Guan, Yan ^{[4
,5
]}

Xiao, Chun-Ling ^{[4
,5
]}

Gao, Hui-Yuan ^{[1
]}

Wu, Li-Jun ^{[1
]}

Tu, Peng-Fei ^{[1
,2
,3
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

[2] Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[3] Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China

[4] Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[5] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

FITOTERAPIA | 2013年 / 89卷

关键词：

Evodia rutaecarpa; Quinolone alkaloids; Antibacterial activity; Cytotoxic activity;

D O I：

10.1016/j.fitote.2013.04.007

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Five new quinolone alkaloids, euocarpines A-E (16-20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7-11, 13, 14, and 16-20 exhibited moderate antibacterial activities (MIC values: 4-128 mu g/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85-56.36 mu M). Crown Copyright (c) 2013 Published by Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

共 26 条

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[2]

Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa [J].