New coumarins and anti-inflammatory constituents from Zanthoxylum avicennae

被引：54

作者：

Cho, Jui-Ying ^{[3
]}

Hwang, Tsong-Long ^{[4
]}

Chang, Tsung-Hsien ^{[5
]}

Lim, Yun-Ping ^{[6
,7
]}

Sung, Ping-Jyun ^{[8
]}

Lee, Tzong-Huei ^{[1
,3
]}

Chen, Jih-Jung ^{[1
,2
]}

机构：

[1] Tajen Univ, Grad Inst Pharmaceut Technol, Yanpu Shiang 907, Pingtung, Taiwan

[2] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[3] Taipei Med Univ, Grad Inst Pharrnacognosy, Taipei 110, Taiwan

[4] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[5] Kaohsiung Vet Gen Hosp, Lab Infect Dis & Immunol, Kaohsiung 813, Taiwan

[6] China Med Univ, Sch Pharm, Coll Pharm, Taichung 404, Taiwan

[7] China Med Univ Hosp, Dept Emergency, Toxicol Ctr, Taichung 404, Taiwan

[8] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 135卷 / 01期

关键词：

Zanthoxylum avicennae; Rutaceae; Structure elucidation; Coumarins; Anti-inflammatory activity; NEUTROPHILS; ALKALOIDS; SCHINIFOLIUM; LEAVES; METABOLITES; CULTURES; INJURY; ROOT; RAT;

D O I：

10.1016/j.foodchem.2012.04.025

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

Zanthoxylum avicennae is commercially used as healthcare products for the improvement of chronic hepatitis and rheumatism. Its fruit is also used as a spice. Five new coumarins, 5'-methoxyauraptene (1), 6,5'-dimethoxyauraptene (2), 5'-methoxycollinin (3), 7-((2'E,5'E)-7'-methoxy-3',7'-dimethylocta-2',5'-dienyloxy)coumarin (4), and 6-methoxy-7-((2'E,5'E)-7'-methoxy-3',7'-dimethylocta-2',5'-dienyloxy)coumarin (5), have been isolated from the leaves of Z. avicennae, together with 15 known compounds (6-20). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 6, 9-15, and 18 exhibited inhibition (IC50 <= 8.29 mu g/ml) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 6, 10, 12, 14, and 18 inhibited fMLP/CB-induced elastase release with IC50 values <= 6.30 mu/ml. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：17 / 23

页数：7

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