Effect of gold nanoparticles on photodynamic efficiency of 5-aminolevolenic acid photosensitiser in epidermal carcinoma cell line: an in vitro study

被引：30

作者：

Amini, Seyed Mohammad ^{[1
]}

Kharrazi, Sharmin ^{[1
]}

Hadizadeh, Mahnaz ^{[2
,3
]}

Fateh, Mohsen ^{[2
,3
]}

Saber, Reza ^{[1
,4
]}

机构：

[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran

[2] Univ Tehran Med Sci, Iranian Ctr Med Lasers, Tehran, Iran

[3] Univ Tehran Med Sci, Acad Ctr Educ Culture & Res, Tehran, Iran

[4] Univ Tehran Med Sci, Res Ctr Sci & Technol Med RCSTIM, Tehran, Iran

来源：

IET NANOBIOTECHNOLOGY | 2013年 / 7卷 / 04期

关键词：

cancer; cellular biophysics; gold; nanoparticles; photodynamic therapy; toxicology; nanomedicine; gold nanoparticle; photodynamic efficiency; 5-aminolevolenic acid photosensitiser; epidermal carcinoma cell line; 5-ALA; cytotoxicity; MTT assay; Au; QUANTUM DOTS; THERAPY; CANCER; SIZE; TOXICITY;

D O I：

10.1049/iet-nbt.2013.0021

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

In the recent years, enhanced functionality of treatment systems based on nanostructures has attracted a lot of interest. Photodynamic therapy (PDT) is one such treatment method. Here, the authors report the results of the investigations on synthesis and characterisation of gold nanoparticles (GNPs) and their application in PDT along with 5-aminolevolenic acid (5-ALA) (as photosensitiser) with no conjugation. Three sizes of GNPs were synthesised and their cytotoxicity was investigated by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on epidermal carcinoma cell line. The results showed that the PDT efficiency of ALA increased in presence of GNPs. This effect was more considerable for 4 nm particles.

引用

页码：151 / 156

页数：6

共 29 条

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