A meta-analysis of alcohol consumption and the risk of brain tumours

被引:31
作者
Galeone, C. [1 ]
Malerba, S. [1 ]
Rota, M. [2 ]
Bagnardi, V. [3 ,4 ]
Negri, E. [1 ]
Scotti, L. [3 ]
Bellocco, R. [3 ,5 ]
Corrao, G. [3 ]
Boffetta, P. [6 ,7 ]
La Vecchia, C. [1 ,7 ,8 ]
Pelucchi, C. [1 ]
机构
[1] Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-20156 Milan, Italy
[2] Univ Milano Bicocca, Dept Clin Med & Prevent, Ctr Biostat Clin Epidemiol, Monza, Italy
[3] Univ Milano Bicocca, Dept Stat, Milan, Italy
[4] European Inst Oncol, Div Epidemiol & Biostat, Milan, Italy
[5] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
[6] Mt Sinai Sch Med, Tisch Canc Inst, Inst Translat Epidemiol, New York, NY USA
[7] Int Prevent Res Inst, Lyon, France
[8] Univ Milan, Dept Clin Med & Community Hlth, Milan, Italy
关键词
alcohol drinking; brain neoplasms; glioma; meningioma; meta-analysis; risk factor; NERVOUS-SYSTEM; CANCER; GLIOMA; MENINGIOMA; COHORT; NITROSAMINES; INDICATORS; MORTALITY; EXPOSURE; SMOKING;
D O I
10.1093/annonc/mds432
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
Alcohol is capable of traversing the blood-brain barrier and is thus a possible risk factor for brain cancer. Several epidemiological studies have been published on the issue, a number of those during recent years, with inconsistent findings. We performed a systematic literature search in the Medline and EMBASE databases. We found a total of 19 studies providing risk estimates for total alcohol or specific alcoholic beverages. Pooled estimates of the relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models. The pooled RR of brain cancer for alcohol drinkers versus non-drinkers was 0.97 (95% CI 0.82-1.15; based on 12 studies). Moderate (< 2 drinks/day) and heavy alcohol drinkers had RRs of 1.01 (95% CI 0.81-1.25) and 1.35 (95% CI 0.85-2.15), respectively. With reference to specific alcoholic beverages, the RRs were 1.01 (95% CI 0.70-1.48) for wine, 0.96 (95% CI 0.82-1.12) for beer, and 1.20 (95% CI 1.01-1.42) for spirit consumption. The RRs for drinkers versus non-drinkers were 0.93 (95% CI 0.81-1.07) for glioma and 0.71 (95% CI 0.45-1.12) for meningioma. Alcohol drinking does not appear to be associated with adult brain cancer, though a potential effect of high doses deserves further study.
引用
收藏
页码:514 / 523
页数:10
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