Studies on the biosynthesis of epothilones:: Hydroxylation of Epo A and B to epothilones E and F

被引：16

作者：

Gerth, K

Steinmetz, H

Höfle, G

Reichenbach, H

机构：

[1] Gesell Biotechnol Forsch mbH, Abt Nat Stoffbiol, D-38124 Braunschweig, Germany

[2] Gesell Biotechnol Forsch mbH, Abt Nat Stoffchem, D-38124 Braunschweig, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2002年 / 55卷 / 01期

关键词：

D O I：

10.7164/antibiotics.55.41

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

When Sorangium cellulosum So ce90 is grown without XAD adsorber resin there is a steady state of epothilone A and B biosynthesis and hydroxylation of these products to epothilones E and F. This biotransformation at position C-21 of the thiazole ring is not restricted to producers of epothilones. It is carried out by a substrate induced monooxygenase. Epothilones E and F are further degraded by opening of the lactone ring by an esterase. Steps of degradation of different strains of S. cellulosum are compared.

引用

页码：41 / 45

页数：5

共 7 条

[1]

IMIDAZOLE ANTIMYCOTICS INHIBITORS OF CYTOCHROME-P450 INCREASE PHOSPHATIDYLSERINE SYNTHESIS SIMILARLY TO K+-CHANNEL BLOCKERS IN JURKAT T-CELLS [J].