Kinase phosphorylation: Keeping it all in the family

被引：100

作者：

Peterson, RT ^{[1
]}

Schreiber, SL

机构：

[1] Harvard Univ, Howard Hughes Med Inst, Cambridge, MA 02138 USA

[2] Harvard Univ, Dept Chem, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Biol Chem, Cambridge, MA 02138 USA

[4] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(99)80326-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The identification of PDK1 as a kinase that phosphorylates the AGC family of kinases led to a hunt for 'PDK2', a hypothetical regulated kinase(s) that would be required for full activation of the AGC kinases. Recent findings suggest that the elusive PDK2 may actually be a familiar kinase with an atypical associate.

引用

页码：R521 / R524

页数：4

共 16 条

[1] Atypical protein kinase Cλ binds and regulates p70 S6 kinase
Akimoto, K
Nakaya, M
Yamanaka, T
Tanaka, J
Matsuda, S
Weng, QP
Avruch, J
Ohno, S
[J]. BIOCHEMICAL JOURNAL, 1998, 335 : 417 - 424
[2] 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase
Alessi, DR
Deak, M
Casamayor, A
Caudwell, FB
Morrice, N
Norman, DG
Gaffney, P
Reese, CB
MacDougall, CN
Harbison, D
Ashworth, A
Bownes, M
[J]. CURRENT BIOLOGY, 1997, 7 (10) : 776 - 789
[3] PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
Balendran, A
Casamayor, A
Deak, M
Paterson, A
Gaffney, P
Currie, R
Downes, CP
Alessi, DR
[J]. CURRENT BIOLOGY, 1999, 9 (08) : 393 - 404
[4] The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
Behn-Krappa, A
Newton, AC
[J]. CURRENT BIOLOGY, 1999, 9 (14) : 728 - 737
[5] Intracellular signalling: PDK1 - a kinase at the hub of things
Belham, C
Wu, SL
Avruch, J
[J]. CURRENT BIOLOGY, 1999, 9 (03) : R93 - R96
[6] CONTROL OF P70 S6 KINASE BY KINASE-ACTIVITY OF FRAP IN-VIVO
BROWN, EJ
BEAL, PA
KEITH, CT
CHEN, J
SHIN, TB
SCHREIBER, SL
[J]. NATURE, 1995, 377 (6548) : 441 - 446
[7] RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
Burnett, PE
Barrow, RK
Cohen, NA
Snyder, SH
Sabatini, DM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) : 1432 - 1437
[8] The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1
Chou, MM
Blenis, J
[J]. CELL, 1996, 85 (04) : 573 - 583
[9] Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
Delcommenne, M
Tan, C
Gray, V
Rue, L
Woodgett, J
Dedhar, S
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) : 11211 - 11216
[10] Protein kinase Cζ is a negative regulator of protein kinase B activity
Doornbos, RP
Theelen, M
van der Hoeven, PCJ
van Blitterswijk, WJ
Verkleij, AJ
Henegouwen, PMPVE
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) : 8589 - 8596

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