The Aging Heart

被引：141

作者：

Chiao, Ying Ann ^{[1
]}

Rabinovitch, Peter S. ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2015年 / 5卷 / 09期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-I; CARDIOVASCULAR-DISEASE ENTERPRISES; CARDIAC PROGENITOR CELLS; TERM CALORIC RESTRICTION; TARGETED PLASTOQUINONE DERIVATIVES; PROMOTES MITOCHONDRIAL BIOGENESIS; RENIN-ANGIOTENSIN SYSTEM; EXTENDS LIFE-SPAN; DIASTOLIC DYSFUNCTION; MAJOR SHAREHOLDERS;

D O I：

10.1101/cshperspect.a025148

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Aging results in progressive deteriorations in the structure and function of the heart and is a dominant risk factor for cardiovascular diseases, the leading cause of death in Western populations. Although the phenotypes of cardiac aging have been well characterized, the molecular mechanisms of cardiac aging are just beginning to be revealed. With the continuously growing elderly population, there is a great need for interventions in cardiac aging. This article will provide an overview of the phenotypic changes of cardiac aging, the molecular mechanisms underlying these changes, and will present some of the recent advances in the development of interventions to delay or reverse cardiac aging.

引用

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