Protein kinase CK2 and cell polarity

被引：13

作者：

Deshiere, Alexandre ^{[1
,2
,3
]}

Theis-Febvre, Nathalie ^{[1
,2
,3
]}

Martel, Veronique ^{[1
,2
,3
]}

Cochet, Claude ^{[1
,2
,3
]}

Filhol, Odile ^{[1
,2
,3
]}

机构：

[1] CEA, iRTSV, DSV, INSERM,U873, F-38054 Grenoble 9, France

[2] CEA, iRTSV, DSV, Lab Transduct Signal, F-38054 Grenoble 9, France

[3] Univ Grenoble 1, F-38000 Grenoble, France

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2008年 / 316卷 / 1-2期

关键词：

protein kinase CK2; localization; polarity; acini; kinase inhibitor; RNA interference;

D O I：

10.1007/s11010-008-9845-y

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is increasing evidence that protein kinase CK2 is involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity. Here, we show that in epithelial cells, a fraction of CK2 is associated to the plasma membrane and that this localization is controlled by cell-matrix interactions. In addition, inhibition of CK2 activity in mammary epithelial cells (MCF10A), using either the specific CK2 inhibitor TBB or siRNA-mediated CK2 beta knockdown, induced differential phenotypes revealing an important role of this enzyme in epithelial cell morphology.

引用

收藏

页码：107 / 113

页数：7

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