Antispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea:: Discrimination between drug and ethanol effects

被引：51

作者：

Meister, A

Bernhardt, G

Christoffel, V

Buschauer, A

机构：

[1] Univ Regensburg, Inst Pharm, D-93053 Regensburg, Germany

[2] Plantamed Arzneimittel GmbH, Neumarkt Opg, Germany

来源：

PLANTA MEDICA | 1999年 / 65卷 / 06期

关键词：

Thymus vulgaris; Lamiaceae; guinea-pig trachea; antispasmodic activity; ethanol;

D O I：

10.1055/s-1999-14006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F-2 alpha). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F-2 alpha being most efficiently antagonized.

引用

页码：512 / 516

页数：5

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