Antimycobacterial triterpenes from Melia volkensii

被引:41
作者
Cantrell, CL
Rajab, MS
Franzblau, SG
Fischer, NH [1 ]
机构
[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA
[2] Gwl Natl Hansens Dis Ctr, Baton Rouge, LA 70894 USA
来源
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 04期
关键词
D O I
10.1021/np980288u
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
In a bioassay-guided search for antimycobacterial compounds from higher plants, we have chemically investigated methanolic extracts of seeds of Melia volkensii. Chromatographic fractions provided two new euphane (20R)-type triterpenoids. The structures of the new compounds, 12 beta-hydroxykulactone (1) and 6 beta-hydroxykulactone (2), were elucidated by 1D and 2D NMR (C-13, H-1, H-1-H-1 COSY, HMQC, HMBC, and NOESY spectra) and FABMS studies and shown to be hydroxyl derivatives of kulactone (3). Also isolated was the known kulonate (4). In a radiorespirometric bioassay against Mycobacterium tuberculosis, compounds 1, 2, and 4 exhibited minimum inhibitory concentrations of 16, 4, and 16 mu g/mL, respectively.
引用
收藏
页码:546 / 548
页数:3
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