Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida

被引：41

作者：

Jeong, TS

Hwang, EI

Lee, HB

Lee, ES

Kim, YK

Min, BS

Bae, KH

Bok, SH

Kim, SU

机构：

[1] KIST, Korea Res Inst Biosci & Biotechnol, Plant Protectants Res Unit, Taejon 305600, South Korea

[2] Korea Res Inst Biosci & Biotechnol, Prot Regulat RU, Taejon, South Korea

[3] Chungnam Natl Univ, Coll Pharm, Dept Pharmacol, Taejon, South Korea

来源：

PLANTA MEDICA | 1999年 / 65卷 / 03期

关键词：

D O I：

10.1055/s-2006-960474

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two triterpenoid compounds, ursolic acid and uvaol, were isolated from Crataegus pinnatifida Bunge leaves. Ursolic acid inhibits chitin synthase II from S. cerevisiae with an IC50 value of 0.84 mu g/ml and the inhibition appears to be selective for chitin synthase II, whereas uvaol has no inhibitory activity up to 280 mu g/ml. Oleanolic acid, alpha-hederin hydrate, and betulic acid inhibited the chitin synthase II activity under the same conditions with an IC50 of 5.6, 64.3, and 98.7 mu g/ml, respectively.

引用

页码：261 / 263

页数：3

共 17 条

[1] CHITIN SYNTHASE-1, AN AUXILIARY ENZYME FOR CHITIN SYNTHESIS IN SACCHAROMYCES-CEREVISIAE [J].