NIKKOMYCIN-Z IS A SPECIFIC INHIBITOR OF SACCHAROMYCES-CEREVISIAE CHITIN SYNTHASE ISOZYME CHS3 IN-VITRO AND IN-VIVO

被引：126

作者：

GAUGHRAN, JP ^{[1
]}

LAI, MH ^{[1
]}

KIRSCH, DR ^{[1
]}

SILVERMAN, SJ ^{[1
]}

机构：

[1] AMER CYANAMID CO,DIV AGR RES,MOLEC GENET SCREEN DESIGN,PRINCETON,NJ 08543

来源：

JOURNAL OF BACTERIOLOGY | 1994年 / 176卷 / 18期

关键词：

D O I：

10.1128/JB.176.18.5857-5860.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nikkomycin Z inhibits chitin synthase in vitro but does not exhibit antifungal activity against many pathogens. Assays of chitin synthase isozymes and growth assays with isozyme mutants were used to demonstrate that nikkomycin Z is a selective inhibitor of chitin synthase 3. The resistance of chitin synthase 2 to nikkomycin Z in vitro is likely responsible for the poor activity of this antibiotic against Saccharomyces cerevisiae.

引用

页码：5857 / 5860

页数：4

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