Intracellular signaling:: Fleshing out the TGFβ pathway

被引：11

作者：

Padgett, RW

机构：

[1] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA

来源：

CURRENT BIOLOGY | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(99)80255-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies of the intracellular signaling pathway initiated by ligands of the transforming growth factor beta (TGF beta) family have provided new insights into how the receptors for such ligands phosphorylate their substrates - the Smads - and how signaling specificity is achieved.

引用

页码：R408 / R411

页数：4

共 17 条

[1] The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
Brummel, T
Abdollah, S
Haerry, TE
Shimell, MJ
Merriam, J
Raftery, L
Wrana, JL
O'Connor, MB
[J]. GENES & DEVELOPMENT, 1999, 13 (01) : 98 - 111
[2] Drosophila dSmad2 and Atr-I transmit activin/TGFβ signals
Das, P
Inoue, H
Baker, JC
Beppu, H
Kawabata, M
Harland, RM
Miyazono, K
Padgett, RW
[J]. GENES TO CELLS, 1999, 4 (02) : 123 - 134
[3] Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases
de Caestecker, MP
Parks, WT
Frank, CJ
Castagnino, P
Bottaro, DP
Roberts, AB
Lechleider, RJ
[J]. GENES & DEVELOPMENT, 1998, 12 (11) : 1587 - 1592
[4] TRANSFORMING GROWTH-FACTOR-BETA (TGF-BETA)-INDUCED DOWN-REGULATION OF CYCLIN-A EXPRESSION REQUIRES A FUNCTIONAL TGF-BETA RECEPTOR COMPLEX - CHARACTERIZATION OF CHIMERIC AND TRUNCATED TYPE-I AND TYPE-II RECEPTORS
FENG, XH
FILVAROFF, EH
DERYNCK, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (41) : 24237 - 24245
[5] TGF-beta signalling from cell membrane to nucleus through SMAD proteins
Heldin, CH
Miyazono, K
tenDijke, P
[J]. NATURE, 1997, 390 (6659) : 465 - 471
[6] Crystal structure of the cytoplasmic domain of the type I TGFβ receptor in complex with FKBP12
Huse, M
Chen, YG
Massagué, J
Kuriyan, J
[J]. CELL, 1999, 96 (03) : 425 - 436
[7] Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
Kretzschmar, M
Doody, J
Massague, J
[J]. NATURE, 1997, 389 (6651) : 618 - 622
[8] Krishna S, 1999, DEVELOPMENT, V126, P251
[9] TGF-β signal transduction
Massagué, J
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 753 - 791
[10] Padgett RW, 1998, BIOESSAYS, V20, P382, DOI 10.1002/(SICI)1521-1878(199805)20:5&lt

← 1 2 →