学术探索
学术期刊
新闻热点
数据分析
智能评审

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

被引：3220
作者：
Heldin, CH [1 ]
Miyazono, K [1 ]
tenDijke, P [1 ]
机构：
[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,TOSHIMA KU,TOKYO 170,JAPAN
来源：
NATURE | 1997年 / 390卷 / 6659期
关键词：
D O I：
10.1038/37284
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs.
引用
收藏
页码：465 / 471
页数：7
相关论文
共 101 条
  • [1] T beta RI phosphorylation of Smad2 on Ser(465) and Ser(467) is required for Smad2-Smad4 complex formation and signaling
    Abdollah, S
    MaciasSilva, M
    Tsukazaki, T
    Hayashi, H
    Attisano, L
    Wrana, JL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) : 27678 - 27685
  • [2] THE DROSOPHILA SCHNURRI GENE ACTS IN THE DPP/TGF-BETA SIGNALING PATHWAY AND ENCODES A TRANSCRIPTION FACTOR HOMOLOGOUS TO THE HUMAN MBP FAMILY
    ARORA, K
    DAI, H
    KAZUKO, SG
    JAMAL, J
    OCONNOR, MB
    LETSOU, A
    WARRIOR, R
    [J]. CELL, 1995, 81 (05) : 781 - 790
  • [3] ATKI A, 1997, J BIOL CHEM, V272, P1429
  • [4] Attisano L, 1996, MOL CELL BIOL, V16, P1066
  • [5] A novel mesoderm inducer, Madr2 functions in the activin signal transduction pathway
    Baker, JC
    Harland, RM
    [J]. GENES & DEVELOPMENT, 1996, 10 (15) : 1880 - 1889
  • [6] TYPE-I RECEPTORS SPECIFY GROWTH-INHIBITORY AND TRANSCRIPTIONAL RESPONSES TO TRANSFORMING GROWTH-FACTOR-BETA AND ACTIVIN
    CARCAMO, J
    WEIS, FMB
    VENTURA, F
    WIESER, R
    WRANA, JL
    ATTISANO, L
    MASSAGUE, J
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) : 3810 - 3821
  • [7] FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors
    Charng, MJ
    Kinnunen, P
    Hawker, J
    Brand, T
    Schneider, MD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) : 22941 - 22944
  • [8] CHEN RH, 1994, J BIOL CHEM, V269, P22868
  • [9] A WD-DOMAIN PROTEIN THAT IS ASSOCIATED WITH AND PHOSPHORYLATED BY THE TYPE-II TGF-BETA RECEPTOR
    CHEN, RH
    MIETTINEN, PJ
    MARUOKA, EM
    CHOY, L
    DERYNCK, R
    [J]. NATURE, 1995, 377 (6549) : 548 - 552
  • [10] INACTIVATION OF THE TYPE-II RECEPTOR REVEALS 2 RECEPTOR PATHWAYS FOR THE DIVERSE TGF-BETA ACTIVITIES
    CHEN, RH
    EBNER, R
    DERYNCK, R
    [J]. SCIENCE, 1993, 260 (5112) : 1335 - 1338
12345678910